I know, I'm still hurting.
They missed both primary endpoints on the SPRINTER trial. Over-achieved on some of the secondary ones though, much better than most existing /in use therapeutics.
Blame has been put on the trial design. But the fact is that by the time phase 3 came along there weren't enough properly ill people.
Also it seems that SoC for people in the right state to join the trial (in the UK at least) would have been given dexamethasone, a corticosteroid, which it's turning out could compromise it
( pubmed.ncbi.nlm.nih.gov/34473766/ ), though it has been paused. They are the only ones left at that stage, all the others have failed.
They've not been thrown off the ACTIv2 programme in the US so there is some hope that a recovery may happened at some point, and a company statement is awaited about whether they will engage in any platform trials. After all, interferon has been postulated time and time again to be beneficial for Covid (and other respiratory illnesses) by an ever-widening array of studies, and it has also been shown to be variant-agnostic.
Everyone was wrong footed, as in the weeks since New Year the com[any engaged a lot of new hires (onto staff, not contract), made a few key partnerships, had a completely redesigned web page. All of that contributed to the expectation that they had seen good things in the trial so it was a surprise when the actual result came through.
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VxFan |
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martin aston |
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10 Dec 21 16:17 |
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10 Dec 21 16:36 |
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10 Dec 21 16:42 |
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10 Dec 21 18:24 |
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10 Dec 21 18:38 |
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smokie |
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10 Dec 21 19:48 |
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smokie |
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10 Dec 21 20:08 |
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11 Dec 21 09:41 |
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12 Dec 21 17:39 |
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sooty123 |
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12 Dec 21 17:51 |
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smokie |
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12 Dec 21 18:18 |
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12 Dec 21 18:47 |
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smokie |
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13 Dec 21 00:36 |
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smokie |
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Zero |
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bathtub tom |
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Lygonos |
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smokie |
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No FM2R |
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13 Dec 21 09:25 |
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legacylad |
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smokie |
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No FM2R |
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13 Dec 21 13:26 |
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Kevin |
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Zero |
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Manatee |
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No FM2R |
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No FM2R |
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15 Dec 21 23:18 |
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Manatee |
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neiltoo |
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VxFan |
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16 Dec 21 12:35 |
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Merck Molnupiravir new |
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Pfizer PAXLOVID new |
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smokie |
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martin aston |
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smokie |
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20 Dec 21 12:44 |
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Manatee |
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20 Dec 21 19:16 |
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Coronavirus Vaccine - New Treatments new |
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Kevin |
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bathtub tom |
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Zero |
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zippy |
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Zero |
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Manatee |
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Terry |
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Kevin |
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Zero |
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Duncan |
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Zero |
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Duncan |
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Zero |
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smokie |
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tyrednemotional |
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Kevin |
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Zero |
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Kevin |
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Kevin |
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tyrednemotional |
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Manatee |
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Fullchat |
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sooty123 |
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Myocarditis risk for ,men under 40 with M.. new |
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a recovery story. new |
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a recovery story. new |
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helicopter |
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a recovery story. new |
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sooty123 |
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Coronavirus Vaccine - Volume 13 new |
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sooty123 |
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23 Jan 22 08:28 |
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Rudedog |
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Bromptonaut |
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smokie |
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sooty123 |
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23 Jan 22 16:17 |
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maltrap |
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23 Jan 22 18:15 |
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sooty123 |
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FDA withdraw Regeneron and bamlanivimab/e.. new |
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Canada anti vax truckers new |
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smokie |
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Canada anti vax truckers new |
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smokie |
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VxFan |
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4 Feb 22 20:11 |
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tyrednemotional |
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4 Feb 22 20:13 |
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smokie |
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4 Feb 22 20:32 |
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VxFan |
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5 Feb 22 20:44 |
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CGNorwich |
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5 Feb 22 20:58 |
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smokie |
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5 Feb 22 22:28 |
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Zero |
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5 Feb 22 22:45 |
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Coronavirus Vaccine - Volume 13 new |
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smokie |
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6 Feb 22 09:44 |
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Rudedog |
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6 Feb 22 13:44 |
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smokie |
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6 Feb 22 14:43 |
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Coronavirus Vaccine - Volume 13 new |
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Zero |
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6 Feb 22 14:52 |
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Coronavirus Vaccine - Volume 13 new |
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smokie |
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6 Feb 22 16:55 |
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Coronavirus Vaccine - Volume 13 new |
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Lygonos |
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14 Mar 22 19:04 |
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smokie |
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Zero |
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