This is the other drug (alongside Merck's pill) which HMG are expecting to dish out to us. Pfizer issued a press release of an interim result, and it's missed its primary endpoint
"the novel primary endpoint of self-reported, sustained alleviation of all symptoms for four consecutive days, as compared to placebo, was not met. The study continues"
where a primary endpoint is "the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment."
There are one or two good secondary outcomes, which is reflected int he final analysis bode reasonably well e.g.
"0.7% of patients who received PAXLOVID were hospitalized through Day 28 following randomization (5/697 hospitalized with no deaths), compared to 6.5% of patients who received placebo and were hospitalized or died (44/682 hospitalized with 9 subsequent deaths)."
and
"PAXLOVID reduced viral load by approximately 10-fold, or 0.93 log10 copies/mL, relative to placebo"outcomes
There are a number of secondary endpoints which "were not yet available for this review".
PR here www.pfizer.com/news/press-release/press-release-detail/pfizer-announces-additional-phase-23-study-results
Trial definition here clinicaltrials.gov/ct2/show/study/NCT05011513
I think it's be quite unusual for a drug which has failed it's primary endpoint to be considered successful, but let's hope the full results tell a different story.
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