While back pain depends on lots of factors (sometimes things beyond your control), I cured my pain in following way.
Following my long commute recently, I had to see my GP due to sudden back pain development. She prescribed some free hand exercise but I finally cured it using following approach.
(Note: I also work with laptop often 8-10 hrs a day and drive 3 hours everyday)
Car
An automatic is better than manual car. However, my car is manual and since my most journey is on motorway, I try to maintain speed so that I don't have to use brake/clutch often. As a result, my 30+30 miles journey on m'way is now more relaxing. If you have cruise control, please make use of it (my car doesn't have it though). Using this strategy helped me a lot.
Adjust your seat lumber support in several angle for few days. For bad angles you'll feel pain every day, with a good posture you suddenly feel you're no longer feeling exhausted (it worked for me at least).
Laptop
Make sure when you work with it, your back side rests on seat back and you are not stooping with a bent back. This is quite important. If you have problem with that posture, use an external keyboard with your laptop (it helped me a lot while working with laptop in my home).
Exercise
Not absolutely necessary IMHO but good if you can manage. But spend 5-10 minutes (yes, that's enough) every day with some free hand exercise.
Hope it helps.
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Back Pain 
Back Pain 