The fatberg should be got rid of, break it up, flush it down the drain and into the sewer - whatever.
Chemicals rely on the drain (a) being slow moving and (b) the point at which the chemical is put in, not being too far from the obstruction, so that the chemicals not being too diluted. If you do use chemicals be very, very, wary about getting into the manhole afterwards, unless the manhole is no more than, say, three feet deep. Certain acids when they come into contact with lime scale can form something similar to phosgene gas (v. nasty). Ask me how I know.
If you leave the rodding eye plug out for a period of time, when the trap blocks and the effluent flows through the cleaning eye, that upstream length of drain will have effluent standing in it, which will allow solids to settle out, thereby leading to your next blockage.
What do your local water authority say? Is it a shared drain?
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