... and I know it's Twitter but this bloke is the Chief Scientific Officer, Nightingale Health. Also leading the Covid-19 genomics initiative @sangerinstitute, who has taken "a look at the spike mutations" and come up with a load of stuff I don't understand but among the related tweets he says
"Finally S477N and Q498R, predicted in an experimental evolution paper to substantially increase ACE2 binding together with N501Y, but only seen in the wild separately or rarely. Seeing this full combination now (along with everything else) is grim."
and
"There are also multiple (possibly funcitonal [sic]) mutations in genes other than spike: notably R203K and G204R in nucleocapsid, which were recently shown to be key in increasing transmissibility, and are present in all VOCs to date."
There are references to other scientists doing related stuff in his tweets if you are interested. His tweet is here, and has a number of parts
twitter.com/jcbarret/status/1463975708770897923?s=21
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