I habitually run my cars at the specified full load pressures, partially because I tow or fit a tow-bar mounted bike carrier regularly and can't be bothered to adjust the pressures down afterwards, partially because of the potentiality greater economy - I do mostly motorway miles.
However, the car was delivered (a year ago) with the tyres inflated to the maximum pressure and I generally manage to get many more miles out of my (company car) tyres than colleagues do and invariably get comments on this from tyre fitters when they're changed. Against this the tyres do tend to wear out slightly quicker in the middle section but possibly only as fast as the edges would were I to run them 'softer'. you so often see cars with the outside edge of their tyres worn away.
The ride is a little harsher but I've never noticed any handling disadvantages - even in the snow. Mine are 225 section run-flats on a 330d.
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